Comparative analysis of the concentrations of proinflammatory cytokines and glycosylated ferritin in patients with idiopathic recurrent pericarditis and adult-onset Still's disease

Idiopathic recurrent pericarditis (IRP) and adult-onset Still's disease (AOSD) are polygenic autoinflammatory diseases, in the pathogenesis of which pro-inflammatory cytokines from interleukin-1 superfamily play a central role. Aim . To compare serum concentrations proinflammatory glycosylated ferritin (GF) patients with IRP AOSD during an exacerbation. Material methods The study included 15 AOSD, — IRP. diagnosis was established using Yamaguchi criteria (1992). diagnosed accordance 2015 European Society Cardiology on management pericardial diseases. Blood sampling all carried out recurrence period prior to anti-inflammatory therapy initiation. levels interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), procalcitonin, total GF assessed. results obtained were compared biochemical parameters, high-sensitivity C-reactive protein (CRP), as well white blood cell (WBC) neutrophil counts. Results median age group 28 years, 55 years. An increase WBC count >10*10 9 /L detected 10 groups, respectively. concentration CRP increased did not differ groups (p=0,836). highest values found (1416 ng/ml vs 408 ng/ml, p=0,008) (12% 33,9%, p=0,067), In both IL-6 IL-18 determined. group, higher than (2114 pg/ml 161,5 pg/ml, p<0,001). (33,9 24,9 p=0,4). IL-1β subjects corresponded normal values. Correlation analysis revealed direct relationship between (r s =0,73, p=0,03). Conclusion similar pattern changes inflammatory biomarkers IRI. most informative marker inflammation IL-18.